2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15358
    15:0-18:1 DG
    		99.0%
    15:0-18:1 DG is a type of diacylglycerol (DAG). 15:0-18:1 DG can be produced by hydrolysis of triacylglycerol (TAG) in butter fat. 15:0-18:1 DG is promising for research of obesity, cardiovascular diseases, and dietary interventions.
    15:0-18:1 DG
  • HY-156645
    Tegomil fumarate
    		99.72%
    Tegomil fumarate is a derivative of Monomethyl fumarate (HY-103252) and an immunomodulator. Tegomil fumarate can be used for the study of relapsing remitting multiple sclerosis.
    Tegomil fumarate
  • HY-W588194
    Cotinine N-β-D-Glucuronide
    Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function.
    Cotinine N-β-D-Glucuronide
  • HY-W717548
    Safinamide acid
    Safinamide acid (Compound Imp-E) is the metabolite of Safinamide (HY-70057). Safinamide acid can be formed by hydrolysis of Safinamide intermediate under alkaline or acidic conditions. Safinamide acid is utilized to monitor process-related impurities and degradation products in safinamide samples.
    Safinamide acid
  • HY-B0794S
    AZ7550-d5
    AZ7550-d5 is the deuterium labeled AZ7550?(HY-B0794). AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of?IGF1R?with an?IC50?of 1.6 μM.
    AZ7550-d<sub>5</sub>
  • HY-100646AS
    (Z)-10-Hydroxynortriptyline-d3
    		99.0%
    (Z)-10-Hydroxynortriptyline-d3 is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (Z)-10-Hydroxynortriptyline-d<sub>3</sub>
  • HY-W011055A
    6-Hydroxycortisol
    6-Hydroxycortisol is the metabolite of Cortisol (HY-N0583). 6-Hydroxycortisol can be used as an indicator of Cortisol metabolism.
    6-Hydroxycortisol
  • HY-W015332
    Captopril EP Impurity D
    Captopril EP Impurity D is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
    Captopril EP Impurity D
  • HY-20874
    Deschlorodemethyldiazepam
    		99.47%
    Deschlorodemethyldiazepam is a benzodiazepines compound. Deschlorodemethyldiazepam can be hydroxylated in vitro by liver microsomal enzymes obtained from rats or mice.
    Deschlorodemethyldiazepam
  • HY-100046S1
    Nordoxepin-d4 hydrochloride
    		99.90%
    Nordoxepin-d4 (Desmethyldoxepin-d4) hydrochloride is deuterium-labeled Nordoxepin (hydrochloride) (HY-100046).
    Nordoxepin-d<sub>4</sub> hydrochloride
  • HY-155792
    Troglitazone glucuronide
    Troglitazone glucuronide (Compound M2) is an initial metabolite of troglitazone in the liver.
    Troglitazone glucuronide
  • HY-G0014
    Quetiapine sulfoxide
    Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine sulfoxide
  • HY-124542
    5-Hydroxydiclofenac
    		98.0%
    5-Hydroxydiclofenac is a major metabolite of Diclofenac (HY-15036). 5-Hydroxydiclofenac is formed by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C189, CYP2C19, and CYP2C8. 5-Hydroxydiclofenac shows apoptotic effects in hepatocytes.
    5-Hydroxydiclofenac
  • HY-131630
    O-Desmethylmetoprolol
    		98.66%
    O-Desmethylmetoprolol is the metabolite of Metoprolol (HY-17503) produced by CYP2D6 enzyme metabolism.
    O-Desmethylmetoprolol
  • HY-W778340
    16α-Hydroxy-11-keto prednisolone
    16α-Hydroxy-11-keto prednisolone (compound M-X) is a metabolite of Budesonide (HY-13580). Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide is a widely used for study of asthma, rhinitis, and inflammatory bowel disease.
    16α-Hydroxy-11-keto prednisolone
  • HY-131314
    Ibuprofen carboxylic acid
    Ibuprofen carboxylic acid is the metabolite of Ibuprofen (HY-78131), that has high concentrations in wastewater and water environments, and disappears fast during biodegradation, compared to the other ibuprofen metabolite.
    Ibuprofen carboxylic acid
  • HY-111177R
    Pheneturide (Standard)
    Pheneturide (Standard) is the analytical standard of Pheneturide. This product is intended for research and analytical applications. Pheneturide (Ethylphenacemide, M 551), a decarboxylation product of Phenobarbital, can be used to prevent psychomotor seizures.
    Pheneturide (Standard)
  • HY-W007077
    (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone
    		Control 99.64%
    (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone is a precursor in the synthesis of benzodiazepines and is also a hydrolysis product of Clonazepam.
    (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone
  • HY-41324R
    7-keto-Deoxycholic acid (Standard)
    7-keto-Deoxycholic acid (Standard) is the analytical standard of 7-keto-Deoxycholic acid. This product is intended for research and analytical applications. 7-keto-Deoxycholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-Deoxycholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition[1][2].
    7-keto-Deoxycholic acid (Standard)
  • HY-W509381
    4-Hydroxyindole-3-acetic acid
    4-Hydroxyindole-3-acetic acid (4HIAA) is a metabolite of Psilocybin and Psilocin.
    4-Hydroxyindole-3-acetic acid
Cat. No. Product Name / Synonyms Application Reactivity